Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
[specimen type], measuring [size] cm in greatest dimension
Diagnosis
Vulvar Large Cell Carcinoma
Classification
Classification: Squamous cell carcinoma, large cell variant, Grade [I/II/III]
Histological Features
Shows large polygonal cells with [nuclear features] and [mitotic activity]
Size and Extent
Size: [X] cm, extent: [local/regional]
Margins
Margins are [involved/uninvolved] with closest margin [X] mm
Lymphovascular Invasion
Lymphovascular invasion: [present/absent]
HPV Status
p16 immunostaining: [positive/negative] (block-type pattern)
Immunohistochemistry
p63: [positive/negative], CK5/6: [positive/negative]
p16: [positive/negative]
[other markers]: [results]
Prognostic Factors
Tumor size, grade, HPV status, lymphovascular invasion
Final Diagnosis
Vulvar Large Cell Carcinoma, Grade [I/II/III], [HPV-related/HPV-independent]