Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
Vaginal biopsy/excision from [location] measuring [size] cm
Diagnosis
Malignant melanoma of vagina
Classification
[Pigmented/Amelanotic] melanoma with [epithelioid/spindle/mixed] morphology
Histological Features
Shows malignant melanocytes with [nuclear features], [pigmentation status], and [growth pattern]
Invasion and Extent
Depth of invasion: [X] mm from mucosal surface, extent: [local/regional]
Mitotic Rate
Mitotic rate: [X] mitoses per mm²
Ulceration
Ulceration: [present/absent]
Margins
Margins are [involved/uninvolved], closest margin [X] mm from tumor
Lymphovascular Invasion
Lymphovascular invasion: [present/absent]
Special Studies
S-100: [positive/negative], SOX10: [positive/negative], Melan-A: [positive/negative]
MITF: [positive/negative], HMB45: [positive/negative]
Cytokeratins: [negative], EMA: [negative]
Molecular Testing
KIT mutation: [positive/negative/not performed], Other mutations: [specify if performed]
AJCC Staging
AJCC Stage: [I/II/III/IV] - [staging description]
Prognostic Factors
Mitotic rate: [X]/mm², Ulceration: [present/absent], Depth: [X]mm, Stage: [I/II/III/IV]
Final Diagnosis
Primary vaginal melanoma, [pigmented/amelanotic], AJCC Stage [I/II/III/IV]