Definition/General
Clinical Features
Master Vaginal Clear Cell Adenocarcinoma Pathology with RxDx
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
Vaginal biopsy/excision from [location] measuring [size] cm
Diagnosis
Clear cell adenocarcinoma of vagina
Classification
Clear cell adenocarcinoma with [predominant architectural pattern]
Histological Features
Shows clear cells with hobnail morphology, [tubulocystic/solid/papillary] architecture, and nuclear atypia
Invasion and Extent
Depth of invasion: [X] mm, extent: [superficial/deep stromal/paravaginal]
Margins
Margins are [involved/uninvolved], closest margin [X] mm from tumor
Lymphovascular Invasion
Lymphovascular invasion: [present/absent]
Special Studies
PAX8: [positive/negative], Napsin A: [positive/negative], CK7: [positive/negative]
HNF1β: [positive/negative], CA125: [positive/negative]
ER: [positive/negative/weak], Ki-67 index: [percentage]%
Clinical Correlation
DES exposure history: [known/unknown/negative], Age: [X] years
FIGO Staging
FIGO Stage: [I/II/III/IV] - [staging description]
Prognostic Factors
DES status: [associated/sporadic], Age: [X] years, Stage: [I/II/III/IV], Size: [X] cm
Final Diagnosis
Primary vaginal clear cell adenocarcinoma, FIGO Stage [I/II/III/IV]