Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
[Unilateral/Bilateral] salpingo-oophorectomy specimen, [right/left] ovary measuring [X x Y x Z] cm, with attached fallopian tube
Gross Description
Complex cystic and solid ovarian mass with papillary projections into cystic spaces, gray-white cut surface, [intact/ruptured] capsule
Diagnosis
Ovarian villoglandular adenocarcinoma
Histological Features
Mixed papillary and glandular architecture, complex branching papillae with fibrovascular cores, well-formed glands within papillary structures, moderate nuclear atypia
Histological Grading
Grade 2 (intermediate grade): moderate nuclear pleomorphism, intermediate mitotic rate ([X] mitoses/10 HPF), glandular differentiation present
Invasion and Extent
Stromal invasion present, [depth] mm, lymphovascular invasion: [present/absent], capsular involvement: [present/absent]
Immunohistochemistry
CK7: Positive, PAX8: Positive, WT1: [Positive/Negative], p53: Wild-type pattern, CK20: Negative, CDX2: Negative, Ki-67: [X]%
Staging (FIGO 2014)
Stage [I/II/III/IV] - [detailed staging criteria based on extent of disease]
Prognostic Factors
Intermediate-grade morphology, villoglandular pattern, [unilateral/bilateral] involvement, stage [X], [lymph node status]
Molecular Testing Recommendations
Consider Lynch syndrome screening if family history present, KRAS/PIK3CA mutation testing for targeted therapy selection may be considered
Comments
Rare variant of ovarian adenocarcinoma with mixed papillary-glandular architecture. Intermediate biological behavior. Multidisciplinary team discussion recommended.
Final Diagnosis
[Unilateral/Bilateral] ovarian villoglandular adenocarcinoma, FIGO Stage [X], Grade 2