Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
Ovarian mass, [side], measuring [X x Y x Z] cm, with [associated structures]
Gross Description
Well-circumscribed mass with pushing borders. Cut surface: solid, fleshy, [color]. Consistency: soft. Necrosis: [present/absent].
Microscopic Findings
Medullary carcinoma with syncytial growth pattern. Extensive lymphocytic infiltrate. Pushing borders. Nuclear grade: [2/3]. Mitotic activity: [count] per 10 HPF.
Immunohistochemistry
CK7: positive. PAX8: positive. p53: [wild-type/aberrant]. MLH1: [retained/lost]. MSH2: [retained/lost]. MSH6: [retained/lost]. PMS2: [retained/lost].
Molecular Studies
MSI status: [MSI-high/MSS]. BRCA1 status: [wild-type/mutated/pending]. MMR gene testing: [recommended/pending].
Diagnosis
Ovarian Medullary Carcinoma [with MSI-high/BRCA1-associated if applicable]
Staging
FIGO Stage: [I/II/III]. TNM: T[X]N[X]M[X]. Lymph nodes: [X] examined, [X] positive.
Genetic Counseling
Recommend genetic counseling for [BRCA1/Lynch syndrome] testing. Family history assessment advised.
Prognostic Factors
Medullary type (favorable prognostic factor). Stage: [early/advanced]. MSI status: [MSI-high/MSS]. BRCA1 status: [mutated/wild-type].
Final Diagnosis
Ovarian Medullary Carcinoma, [unilateral/bilateral], FIGO Stage [X], [MSI-high/BRCA1-associated if applicable]