Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
[Unilateral/Bilateral] salpingo-oophorectomy with SEE-FIM protocol, fallopian tube measuring [size] cm
Diagnosis
High-grade serous carcinoma of fallopian tube
Classification
High-grade serous adenocarcinoma (Grade 3)
Histological Features
Shows complex papillary architecture with high-grade nuclear atypia, prominent nucleoli, and high mitotic activity
Site of Origin
Primary site: [fimbrial/ampullary], with transition from normal tubal epithelium
STIC (Serous Tubal Intraepithelial Carcinoma)
STIC: [present/absent], Distribution: [focal/multifocal], Location: [fimbrial/ampullary]
Extent of Disease
Size: [X] cm, Invasion: [through tubal wall], Serosal involvement: [present/absent]
Ovarian Involvement
Ovarian surface: [involved/uninvolved], Pattern: [surface implants/stromal invasion]
Lymphovascular Invasion
Lymphovascular invasion: [present/absent]
Special Studies
PAX8: positive, WT1: [positive/negative], CK7: positive
p53: [aberrant overexpression/null pattern] - consistent with TP53 mutation
Ki-67 index: [high, >50%]
Molecular Testing Recommendations
BRCA1/2 germline testing: recommended for all patients. HRD testing: consider for treatment planning
FIGO Staging
FIGO Stage: [IA/IB/IC/II/III/IV] - [staging details]
Prognostic Factors
High-grade serous carcinoma, Stage: [I/II/III/IV], LVI: [present/absent], BRCA status: [pending testing]
Final Diagnosis
Primary fallopian tube high-grade serous carcinoma, FIGO Stage [IA/IB/IC/II/III/IV]