Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
[specimen type], measuring [size] cm, soft consistency
Diagnosis
Endometrial adenocarcinoma, medullary type
WHO Classification
Endometrial adenocarcinoma, special variant (medullary type)
Histological Features
Solid growth pattern with pushing borders and prominent lymphocytic infiltrate
Grade
FIGO Grade: 3 (morphologically high-grade)
Tumor Borders
Tumor borders: Pushing margins with peritumoral lymphocytes
Mismatch Repair Proteins
MLH1: [retained/lost], MSH2: [retained/lost], MSH6: [retained/lost], PMS2: [retained/lost]
p53: [wild-type/overexpressed], Ki-67: [percentage]%
PD-L1: [positive/negative]
Molecular Studies
Microsatellite instability: [MSI-high/MSS/pending]
Lynch Syndrome Screening
Mismatch repair deficiency identified, recommend genetic counseling
Final Diagnosis
Endometrial adenocarcinoma, medullary type, mismatch repair deficient