Definition/General
Clinical Features
Master Secretory Carcinoma Pathology with RxDx
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
Radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection, received [fresh/in formalin]
Diagnosis
Cervical secretory carcinoma with ETV6-NTRK3 fusion
Histological Features
Microcystic and tubular architecture with abundant intraluminal eosinophilic secretions, vacuolated cells, and low-grade nuclear features
Tumor Size
Greatest dimension: [X] cm; Additional dimensions: [X] × [X] cm
Depth of Invasion
Depth of stromal invasion: [X] mm; Cervical wall thickness: [X] mm; Percentage of wall invasion: [X]%
Margins
Ectocervical margin: [Negative/Positive] ([X] mm); Endocervical margin: [Negative/Positive] ([X] mm); Deep stromal margin: [Negative/Positive] ([X] mm)
Lymphovascular Invasion
[Absent/Present]; If present: [focal/multifocal]
Parametrial Involvement
Right parametrium: [Not involved/Involved]; Left parametrium: [Not involved/Involved]
Lymph Nodes
Total nodes examined: [X]; Positive nodes: [X]
Immunohistochemistry
S100: Positive; Mammaglobin: Positive; SOX10: Positive; Pan-TRK: Positive; p16: Negative; CK7: Positive
Molecular Testing
ETV6-NTRK3 fusion: Detected by [FISH/RT-PCR/NGS]; HPV ISH: Negative
Pathological Stage
FIGO Stage (2018): [stage]; TNM Stage (8th edition): pT[X]N[X]M[X]
Additional Findings
[Background cervical changes/Other findings]