Definition/General
Clinical Features
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Gross Description
Microscopic Description
Immunohistochemistry
Molecular/Genetic
Differential Diagnosis
Sample Pathology Report
Template Format
Sample Pathology Report
Complete Report: This is an example of how the final pathology report should be structured for this condition.
Specimen Information
Specimen: [Lumpectomy/Mastectomy]\nSpecimen Size: [X x Y x Z cm]\nTumor Location: [Quadrant/Clock position]
Diagnosis
Invasive adenoid cystic carcinoma, breast\nHistologic Pattern: [Cribriform/Tubular/Solid/Mixed]
Tumor Size
Invasive Carcinoma Size: [X.X cm]\nIn Situ Component: [Present/Absent]
Histologic Grade
Nottingham Grade: [1/2/3] (Tubule formation: [1-3], Nuclear grade: [1-3], Mitotic rate: [1-3])
Margins
Superior: [Negative/Positive] - closest distance [X mm]\nInferior: [Negative/Positive] - closest distance [X mm]\nAnterior: [Negative/Positive] - closest distance [X mm]\nPosterior: [Negative/Positive] - closest distance [X mm]\nMedial: [Negative/Positive] - closest distance [X mm]\nLateral: [Negative/Positive] - closest distance [X mm]
Lymphovascular Invasion
Lymphovascular invasion: [Not identified/Present]\n[If present: Extensive/Focal]
Hormone Receptors
Estrogen Receptor: Negative (0%)\nProgesterone Receptor: Negative (0%)\nHER2: [Score 0/1+/2+/3+]\n[If 2+: HER2 ISH result]
Special Studies
Immunohistochemistry: p63: Positive (myoepithelial cells)\nSMA: Positive (myoepithelial cells)\nCK7: Positive (ductal cells)\nKi-67: [X]% (low proliferation)
Molecular Studies: [If performed]\nMYB-NFIB fusion: [Positive/Negative/Not performed]
Lymph Nodes
Lymph Nodes: [Number examined]\nPositive Nodes: [Number positive]\nExtranodal Extension: [Present/Absent/Not applicable]
Pathologic Stage (AJCC 8th Edition)
pT: [T1a/T1b/T1c/T2/T3/T4]\npN: [N0/N1/N2/N3]\nOverall Stage: [I/II/III]
Additional Findings
Background Breast Tissue: [Normal/Benign changes]\nCalcifications: [Present/Absent]\nOther: [Specify any additional findings]
Comments
Adenoid cystic carcinoma is a rare special type breast carcinoma with generally favorable prognosis. Triple-negative immunophenotype is characteristic. Consider genetic counseling for BRCA1 testing.